Acid-Resistant Capsules
Innoval Pharma offers next-generation acid-resistant capsules designed to protect sensitive active pharmaceutical ingredients (APIs) from the harsh acidic environment of the stomach. Unlike conventional enteric-coated capsules that require post-filling processing—often involving organic solvents, heat treatment, and additional drying steps—our proprietary capsule technology delivers robust gastric protection without compromising API integrity. The capsule remains fully intact in gastric conditions (pH 1.2) for over two hours, then reliably dissolves in the small intestine at pH 6.8, enabling targeted intestinal delivery. This innovative approach simplifies the manufacturing process, accelerates time to market, and ensures consistent product performance. Whether you are developing acid-labile biologics, small molecules, probiotics, or oral vaccines, Innoval Pharma acid-resistant capsules provide a dependable solution for oral drug delivery.
Acid-Resistant Capsules
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Benefits
Our acid-resistant capsules prevent premature release of active pharmaceutical ingredients in the stomach, shielding them from degradation caused by gastric acid (pH 1.2–3.5). This protection ensures that sensitive compounds—including peptides, proteins, live biotherapeutics, and probiotics—reach the small intestine intact, where absorption is optimal.
Traditional enteric delivery requires an additional coating step after capsule filling, often involving solvents and heat that can damage APIs. Our ready-to-fill capsules are intrinsically acid-resistant, eliminating secondary processing. This reduces manufacturing complexity, lowers production costs, and removes the risk of API degradation during coating or drying.
The capsule is engineered to resist dissolution in the stomach and release its payload precisely in the small intestine at pH 6.8. Through customization, release profiles can be tailored to target specific intestinal regions—from the duodenum to the distal ileum or even the colon—optimizing bioavailability for a wide range of therapeutic applications.
We provide full regulatory acceptance for pharmaceutical applications. Available in a full range of sizes with customizable coloration options, they integrate seamlessly into existing high-speed filling lines and scale efficiently from development to commercial production.
Our acid-resistant capsules prevent premature release of active pharmaceutical ingredients in the stomach, shielding them from degradation caused by gastric acid (pH 1.2–3.5). This protection ensures that sensitive compounds—including peptides, proteins, live biotherapeutics, and probiotics—reach the small intestine intact, where absorption is optimal.
Traditional enteric delivery requires an additional coating step after capsule filling, often involving solvents and heat that can damage APIs. Our ready-to-fill capsules are intrinsically acid-resistant, eliminating secondary processing. This reduces manufacturing complexity, lowers production costs, and removes the risk of API degradation during coating or drying.
The capsule is engineered to resist dissolution in the stomach and release its payload precisely in the small intestine at pH 6.8. Through customization, release profiles can be tailored to target specific intestinal regions—from the duodenum to the distal ileum or even the colon—optimizing bioavailability for a wide range of therapeutic applications.
We provide full regulatory acceptance for pharmaceutical applications. Available in a full range of sizes with customizable coloration options, they integrate seamlessly into existing high-speed filling lines and scale efficiently from development to commercial production.
FAQ
How do your acid-resistant capsules differ from traditional enteric-coated capsules?
Traditional enteric capsules rely on a secondary coating applied after filling, which requires solvents and heat treatment—steps that can degrade sensitive APIs and add manufacturing complexity. In contrast, Innoval Pharma acid-resistant capsules are intrinsically acid-resistant, eliminating the need for post-filling coating, sealing, or drying. This simplifies production, protects API integrity, and accelerates development timelines.
What types of APIs are best suited for your acid-resistant capsules?
Our capsules are ideal for any API that is unstable in gastric acid or causes gastric irritation. Common applications include acid-labile biologics (peptides, proteins, monoclonal antibodies), probiotics and live biotherapeutic products, oral vaccines, small molecules with poor gastric stability, and NSAIDs that may irritate the gastric mucosa. The capsule ensures these sensitive compounds reach the small intestine intact for optimal absorption.
How long does the capsule resist gastric acid, and at what pH does it release?
The capsule remains fully intact in simulated gastric fluid at pH 1.2 for over two hours, meeting compendial acid-resistance requirements. Upon entering the small intestine, where pH typically ranges from 6.0 to 7.4, the capsule reliably opens and releases its contents. Through our customization capabilities, dissolution profiles can be tailored to target specific pH thresholds for site-specific delivery.
Can these capsules be used with moisture-sensitive formulations?
Yes. Our acid-resistant capsules are formulated with a low moisture content (typically 4%–10%), making them particularly suitable for moisture-sensitive or hygroscopic APIs. The capsule material provides excellent stability across a wide range of temperature and humidity conditions, ensuring product integrity throughout manufacturing, storage, and distribution.
Are your acid-resistant capsules compatible with standard filling equipment?
Absolutely. Our capsules are designed to run seamlessly on standard high-speed capsule filling equipment. They are available in a full range of sizes and can be customized with various coloration, finishing, and printing options to meet brand specifications. This compatibility allows for a smooth transition from development to commercial-scale manufacturing without requiring specialized equipment investments.
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